Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

Céline Bellenguez,Steve Bevan,Andreas Gschwendtner,Chris C A Spencer,Annette I Burgess,Matti Pirinen,Caroline A Jackson,Matthew Traylor,Amy Strange,Zhan Su,Gavin Band,Paul D Syme,Rainer Malik,Joanna Pera,Bo Norrving,Robin Lemmens,Colin Freeman, Renata Schanz, Tom James,Deborah Poole,Lee Murphy,Helen Segal,Lynelle Cortellini,Yu-Ching Cheng,Daniel Woo,Michael A Nalls,Bertram Müller-Myhsok,Christa Meisinger,Udo Seedorf,Helen Ross-Adams,Steven Boonen, Dorota Wloch-Kopec,Valerie Valant,Julia Slark,Karen Furie,Hossein Delavaran,Cordelia Langford,Panos Deloukas,Sarah Edkins, Sarah Hunt,Emma Gray,Serge Dronov,Leena Peltonen,Solveig Gretarsdottir,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Kari Stefansson,Giorgio B Boncoraglio,Eugenio A Parati,John Attia,Elizabeth Holliday,Chris Levi,Maria-Grazia Franzosi,Anuj Goel,Anna Helgadottir,Jenefer M Blackwell,Elvira Bramon,Matthew A Brown,Juan P Casas,Aiden Corvin,Audrey Duncanson,Janusz Jankowski,Christopher G Mathew,Colin N A Palmer,Robert Plomin,Anna Rautanen,Stephen J Sawcer,Richard C Trembath,Ananth C Viswanathan,Nicholas W Wood,Bradford B Worrall,Steven J Kittner,Braxton D Mitchell,Brett Kissela,James F Meschia,Vincent Thijs,Arne Lindgren,Mary Joan Macleod,Agnieszka Slowik,Matthew Walters,Jonathan Rosand,Pankaj Sharma,Martin Farrall,Cathie L M Sudlow,Peter M Rothwell,Martin Dichgans,Peter Donnelly,Hugh S Markus

NATURE GENETICS（2012）

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摘要

Hugh Markus, Peter Donnelly and colleagues report a genome-wide association study for ischemic stroke. They identify a SNP in HDAC9 , a histone deacetylase gene, that is associated with large vessel ischemic stroke and suggest subtype-specific associations to ischemic stroke.

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关键词

gene locus,genetic code,polymorphism,genome wide association study,chromosomes,risk,confidence interval,stroke,genetic heterogeneity,odds ratio,repressor proteins,genetic variability,genetic association,gene,genotype

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