BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia

Oliver Hantschel, Wolfgang Warsch,Eva Eckelhart,Ines Kaupe,Florian Grebien,Kay-Uwe Wagner,Giulio Superti-Furga,Veronika Sexl

Nature chemical biology（2012）

引用 170|浏览7

暂无评分

摘要

lthough JAK2 inhibitors were proposed to be beneficial in chronic myeloid leukemia, myeloid transformation and STAT5 activation in BCR-ABL–positive leukemias are JAK2 independent. Mechanistic investigations reveal that certain JAK2 inhibitors act via off-target inhibition of BCR-ABL.

查看译文

关键词

nature chemical biology, science

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要