Clinical, molecular, and genetic correlates of lymphatic spread in clear cell renal cell carcinoma.

Nils Kroeger,David B Seligson,Tobias Klatte,Edward N Rampersaud,Frédéric D Birkhäuser,P Nagesh Rao,John T Leppert,Nazy Zomorodian,Fairooz F Kabbinavar,Arie S Belldegrun,Allan J Pantuck

European Urology（2012）

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摘要

Lymph node–positive clear cell renal cell carcinomas (RCCs) are more likely to be wild-type von Hippel-Lindau tumors, to express low carbonic anhydrase IX, and to have the worst prognosis and are poor immunotherapy responders, like non–clear cell RCCs.

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关键词

Renal cell carcinoma,Lymph nodes,CAIX,VEGF,VEGF receptor,Loss 3p,VHL gene

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