Use Of Fluoroalkyl As A Latent Group For Internal Alkylation: Application To The Synthesis Of Bridged Tetrahydrofluorenones
ORGANIC LETTERS(2008)
摘要
Tetrahydrofluorenones which possess a C9a-fluoroalkyl substituent were efficiently converted to tetrahydrofluorenones which contain a ring bridging C9a-C2. Conditions include a stepwise sequence of conversion to an alkyl bromide followed by treatment with base, and a direct cyclization by treatment with lithium chloride in DMF heated to 150 degrees C.
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