Cyclic Imides As Potent And Selective Alpha-1a Adrenergic Receptor Antagonists.

Rm Dipardo,Ma Patane, Rp Price,Rc Newton,J Disalvo, Tp Broten,Rsl Chang, Rw Ransom, Rm Freidlinger,Mg Bock

Bioorganic & medicinal chemistry letters（2000）

引用 27|浏览2

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摘要

We disclose a new compound class of potent and selective alpha-1A adrenergic receptor antagonists exemplified by the geminally, disubstituted cyclic imide 7. The optimization of lead compounds resulting in the cyclic imide motif is highlighted. The results of in vitro and in vivo studies of selected compounds are presented.

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