Angiotensin-converting enzyme and genetics at high altitude

    High altitude medicine & biology, Volume 2, Issue 2, 2001, Pages 201-210.

    Cited by: 24|Bibtex|Views1|Links
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    Keywords:
    hypoxiageneticshypoxic pulmonary vasoconstrictionangiotensin converting enzymehigh altitude

    Abstract:

    As part of the renin-angiotensin system (RAS), angiotensin-converting enzyme (ACE) plays a key role in circulatory homeostasis. ACE degrades vasodilator kinins and generates angiotensin II. A polymorphism in intron 16 of the human ACE gene has been identified in which the presence (insertion, I allele) rather than the absence (deletion, D...More

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