Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.

Andrea P Caminos,Esteban A Panozzo-Zenere,Shane R Wilkinson,Babu L Tekwani,Guillermo R Labadie

Bioorganic & Medicinal Chemistry Letters（2012）

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摘要

A series of N,N′-substituted diamines were prepared. The most potent compounds have 50% parasite growth inhibition at submicromolar (against Trypanosoma cruzi) or nanomolar (against Trypanosoma brucei and Leishmania donovani) range.

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关键词

Leishmaniasis,Chagas’ disease,Human African trypanosomiasis,Diamines,Reductive amination

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