Synthesis of new 4,5-dihydrofuranoindoles and their evaluation as HCV NS5B polymerase inhibitors.

Francisco Velázquez,Srikanth Venkatraman,Charles A Lesburg,José Duca,Stuart B Rosenblum,Joseph A Kozlowski,F George Njoroge

ORGANIC LETTERS（2012）

引用 23|浏览8

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摘要

The synthesis of substituted 3,4-dihydrofuranoindoles is reported. These new indole compounds were used to synthesize potent HCV NS5B inhibitors. The binding mode of the dihydrofuranoindole-derived inhibitors was established via X-ray crystallographic studies.

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