Orally bioavailable allosteric CCR8 antagonists inhibit dendritic cell, T cell and eosinophil migration.

Stephen Connolly,Marco Skrinjar,Alexander Rosendahl

Biochemical Pharmacology（2012）

引用 14|浏览7

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摘要

The chemokine receptor CCR8 is associated with asthma. Herein, we describe that both mature and immature dendritic cells (DC) express CCR8, whereas only mature DC migrate towards CCL1. Moreover, transient LPS challenge significantly down-regulates CCR8 expression hence attenuating CCL1 chemotaxis.

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关键词

DC,LPS,PK,GPCR,hERG,FEV1,KO,wt,CYP,MEC,DtM,SPA,BSA,HLM

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