Synthesis and evaluation of novel modified γ-lactam prostanoids as EP4 subtype-selective agonists.
Bioorganic & Medicinal Chemistry（2012）
摘要
The 2-oxo-1,3-oxazoline, 2-oxo-1,3-thiazolidine and 5-thioxopyrrolidine were identified as new templates for EP4 receptor selective agonists.
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关键词
Prostaglandin,EP4 receptor,Agonist,TNF-alpha
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