Time course of treatment effect of OROS® methylphenidate in children with ADHD.

Objective: The authors evaluated the time course of the treatment effect of Osmotic-Release Oral System methylphenidate (OROS (R) MPH) HCl (Concerta (R), Raritan, NJ) CII in children with ADHD. Method: Data were combined from two double-blind, randomized, placebo-controlled, cross-over, analog classroom studies in children (9-12 years) with ADHD. Participants received an individualized dose of placebo or OROS (R) MPH on two laboratory school days. Permanent Product Math Test and Swanson, Kotkin, Agler, M-Flynn, and Pelham scores were evaluated 0.5 hr before dosing and 1, 2, 4, 10, 11, and 12.5 hr post dose. Analysis used a repeated-measures mixed model. Results: Treatment effects were present at all postdose assessment points (p < .0001 for all comparisons, n = 139). Adverse events were similar to previous reports for OROS (R) MPH. Conclusion: A robust treatment effect occurred with OROS (R) MPH; onset was at 1 hr and persisted for at least 12.5 hr after dosing. (J. of Att. Dis. 2012; 16(8) 697-705)