Hepatitis C virus epitope exposure and neutralization by antibodies is affected by time and temperature

    Virology, Volume 422, Issue 2, 2012, Pages 174-184.

    Cited by: 22|Bibtex|Views1|Links
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    Keywords:
    cell linekineticsantibodyepitopesstructureMore(2+)

    Abstract:

    A recent study with flaviviruses suggested that structural dynamics of the virion impact antibody neutralization via exposure of ostensibly cryptic epitopes. To determine whether this holds true for the distantly related hepatitis C virus (HCV), whose neutralizing epitopes may be obscured by a glycan shield, apolipoprotein interactions, a...More

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