Comment on: Wilson et al. Persistence of individual variations in glycated hemoglobin: analysis of data from the juvenile diabetes research foundation continuous glucose monitoring randomized trial. Diabetes Care 2011;34:1315-1317.

We thank Hempe et al. (1) for their comments and the opportunity to further discuss this issue. They question why we switched from use of hemoglobin glycation index (HGI) (2) to ratios in our analyses of the relation between HbA1c and mean glucose (MG). They suggest that the HGI is superior to the MG-to-HbA1c ratio. We actually performed parallel analyses with the ratio and the HGI. Because of space limitations, our article focused on results from the ratio, but we did show that results were similar using HGI. This was stated in the article, and the HGI data were made available in supplemental materials on the journal website. As is often the case when considering different …