Principle: A Tool For Associating Genes With Diseases Via Network Propagation

Assaf Gottlieb,Oded Magger,Igor Berman,Eytan Ruppin,Roded Sharan

BIOINFORMATICS（2011）

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摘要

PRINCIPLE is a Java application implemented as a Cytoscape plug-in, based on a previously published algorithm, PRINCE. Given a query disease, it prioritizes disease-related genes based on their closeness in a protein-protein interaction network to genes causing phenotypically similar disorders to the query disease.

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