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7-Oxopyrrolopyridine-derived DPP4 Inhibitors-Mitigation of CYP and Herg Liabilities Via Introduction of Polar Functionalities in the Active Site.

Wei Wang,Pratik Devasthale,Aiying Wang,Tom Harrity,Don Egan,Nathan Morgan,Michael Cap,Aberra Fura,Herbert E. Klei,Kevin Kish,Carolyn Weigelt,Lucy Sun,Paul Levesque,Yi-Xin Li,Robert Zahler,Mark S. Kirby,Lawrence G. Hamann

Bioorganic & Medicinal Chemistry Letters（2011）

引用 19|浏览32
关键词
DPP4 inhibitors,7-Oxopyrrolopyridines,Atropisomers,Diabetes mellitus
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