Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M.

Marion Rusch,Tobias J Zimmermann,Marco Bürger,Frank J Dekker,Kristina Görmer,Gemma Triola,Andreas Brockmeyer,Petra Janning,Thomas Böttcher,Stephan A Sieber,Ingrid R Vetter,Christian Hedberg,Herbert Waldmann

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION（2011）

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摘要

Finding the target: activity-based proteomic profiling probes based on the depalmitoylation inhibitors palmostatin B and M have been synthesized and were found to target acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells.

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关键词

acyl protein thioesterase,inhibition,proteomics,Ras proteins,signal transduction

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