Selection of an M184V mutation in the cerebrospinal fluid of a treatment-naive HIV-infected individual starting darunavir-based therapy.

Marion Cornelissen,Nicole K T Back,David M Burger,Petra Blom,Peter Portegies,Jan M Prins,Marc van der Valk

ANTIVIRAL THERAPY（2011）

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摘要

Here, we describe a newly diagnosed HIV-1-infected patient, in whom shortly after the initiation of a darunavir-based regimen, the HIV-1 virus exclusively mutated in the cerebrospinal fluid (CSF), leading to an increase in CSF HIV-1 RNA load and neurological complaints.

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