Convenient Syntheses of 6-Methylpurine and Related Nucleosides

Hassan A E,Abou-Elkair R A,Montgomery J A,Secrist J A

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS（2000）

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摘要

Efficient methods for the synthesis of 6-methylpurine (3), 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-methylpurine (8), and 6-methyl-9-beta-D-ribofuranosylpurine (5) are described. Methodology involving the (Ph3P)(4)Pd catalyzed cross-coupling reaction of CH3ZnBr with several different 6-chloropurine derivatives is described in high yield. This methodology now provides a facile and high-yielding synthesis of 8, which is needed in significant amounts for studies in cancer gene therapy.

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