Pharmacokinetics and protein binding of linezolid in cerebrospinal fluid and serum in a case of post-neurosurgical bacterial meningitis.

Yasuhiro Tsuji,Yoichi Hiraki,Kana Matsumoto,Akiko Mizoguchi,Shinichi Sadoh,Tsutomu Kobayashi,Yusuke Takemura,Seisaburo Sakamoto,Kunihiko Morita,Hidetoshi Kamimura,Yoshiharu Karube

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES（2011）

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摘要

We describe a case of bacterial meningitis in a patient administered linezolid (LZD). The ratio of free to total LZD concentrations in cerebrospinal fluid (CSF) was 1 for all measurements, and the LZD concentration in CSF measured at the trough level was almost the same as the free serum concentration.

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Linezolid,bacterial meningitis,protein binding ratio,cerebrospinal fluid

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