Detection Of Estrogen Receptor-Beta Mrna In Breast Cancer Using Rt-Pcr
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS(2000)
摘要
The estrogen receptor (ER) is the most useful marker currently available for breast cancer being used both to predict response to therapy and assess prognosis. Recently, a new form of the ER, known as ER-beta, was identified. In this preliminary study we show that ER-beta mRNA was expressed less frequently in breast cancers than ER-alpha. ER-alpha but not ER-beta levels correlated with ER protein as determined by ELISA. We conclude that ER-beta is expressed in approximately 50% of breast cancers but it does not appear to be detected by a widely available ELISA.
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关键词
estrogen receptor-alpha, estrogen receptor-beta, breast cancer, prognosis
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