Relative HLA-DRB1∗13 allele frequencies and DRB3 associations of unrelated individuals from five US populations
Human Immunology(1999)
摘要
The frequencies of 30 HLA-DRB1∗13 alleles and 15 DRB3 alleles were determined for the 5 major U.S. ethnic populations: Caucasians, African Americans, Asian/Pacific Islanders, Hispanics, and Native Americans. A random sampling (163) of DRB1∗13-positive individuals from each self-described ethnic group was selected out of a pool of 82,979 unrelated individuals, providing at least an 80% probability of detecting a rare allele that occurred at 1%. These 815 samples were subjected to allele-level SSOP typing and/or DNA sequencing which identified 11 different DRB1∗13 alleles. DRB1∗1301 and DRB1∗1302 were the most common alleles seen in the five major ethnic groups while DRB1∗1304 was not detected among Caucasians and DRB1∗1305 was not detected among African Americans. DRB1∗13 allele diversity was surprisingly more limited among African Americans compared to both Caucasians and Asian/Pacific Islanders. To determine the extent of DRB1∗13-DRB3 associations, 504 of these samples expressing only one DRB3-associated DRB1 allele were subjected to PCR-SSOP typing and 14 DRB1∗13-DRB3 haplotypes were detected. The distribution revealed that African Americans were significantly different from Caucasians, Asian/Pacific Islanders, and Hispanics. Allele frequency studies such as this further support previous findings that the distribution of HLA types can differ significantly among different ethnic populations.
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关键词
HLA-DRB1∗13,DRB3,PCR-SSOP,allele frequency
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