Functional conservation of the human EXT1 tumor suppressor gene and its Drosophila homolog tout velu
Development genes and evolution(2007)
摘要
Heparan sulfate proteoglycans play a vital role in signaling of various growth factors in both Drosophila and vertebrates. In Drosophila , mutations in the tout velu ( ttv ) gene, a homolog of the mammalian EXT1 tumor suppressor gene, leads to abrogation of glycosaminoglycan (GAG) biosynthesis. This impairs distribution and signaling activities of various morphogens such as Hedgehog (Hh), Wingless (Wg), and Decapentaplegic (Dpp). Mutations in members of the exostosin ( EXT ) gene family lead to hereditary multiple exostosis in humans leading to bone outgrowths and tumors. In this study, we provide genetic and biochemical evidence that the human EXT1 ( hEXT1 ) gene is conserved through species and can functionally complement the ttv mutation in Drosophila . The hEXT1 gene was able to rescue a ttv null mutant to adulthood and restore GAG biosynthesis.
更多查看译文
关键词
Drosophila,HSPGs,EXT,Conservation,Evolution
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要