Rapid HATU-mediated solution phase siRNA conjugation.

Jeffrey G Aaronson,Lee J Klein,Aaron A Momose,Ann M O'Brien,Anthony W Shaw,Thomas J Tucker,Yu Yuan,David M Tellers

BIOCONJUGATE CHEMISTRY（2011）

引用 12|浏览2

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摘要

Conditions for facile solution-phase amide conjugation of amine-modified siRNA with a diverse set of carboxylic acid partners using the coupling reagent HATU are described. These conditions eliminate the need for isolated activated esters and allow for rapid access to conjugates with a wide range of lipophilicity and functionality in good yield.

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