Functional capacity of the thyroid autograft and heterograft: An experimental study.

Background The aim of this study was to investigate the functional capacity of thyroid autografts/heterografts in a guinea pig model. Methods. A total of 24 guinea pigs were divided into 4 groups. Group A had only a thyroidectomy incision, and group B had total thyroidectomy. We performed autotransplantation in group C and heterotransplantation in group D. We monitored the guinea pigs for an 8-week period, with weekly measurements of free triiodothyronine (fT3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH). At the final stage, the autografts/ heterografts were histologically examined. Results. In group B, fT3/fT4 showed a gradual decrease; however, an increase of TSH was noted. In groups C and D, fT3/fT4 showed a gradual decrease, followed by a gradual increase until euthyroid levels; an exact opposite was noted for TSH. In histologic examination, there were functional thyroid follicles in all animals of groups C and D. Conclusions. The autotransplanted/heterotransplanted guinea pig's thyroid tissue provides adequate thyroid function. VVC 2011 Wiley Periodicals, Inc. Head Neck 34: 702-708, 2012