Human Cts18.1 Gene: Chromosomal Localization And Ph-Domain Analysis

The human cts18.1 gene has high homology with the cytohesin gene family. By PCR analysis of a human monochromosomal somatic cell hybrid DNA panel, the cts18.1 gene was localized to chromosome 19. Diversity values of synonymous and nonsynonymous substitutions indicate that negative selection has occurred in the pleckstrin-homology (PH) domain of the cytohesin gene family. The phylogenetic tree calculated by the neighbor-joining method suggests that cts18.1 and cytohesin-2 genes are more closely related to each other than either of them is to the CLM-2 gene in the analysis of cDNA of the PH domain.