Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination

Sha Mi,Xinhua Lee,Yinghui Hu,Benxiu Ji,Zhaohui Shao,Weixing Yang,Guanrong Huang, Lee Walus,Kenneth Rhodes, Bang Jian Gong,Robert H Miller,R Blake Pepinsky

NATURE MEDICINE（2011）

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摘要

The multiple sclerosis brain shows massive demyelination. Now, Sha Mi and colleagues show that upregulation of DR6 in multiple sclerosis brain is responsible for inhibiting remyelination and brain repair by oligodendrocytes.

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nature medicine, science

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