The discovery and structure-activity relationships of pyrano[3,4-b]indole-based inhibitors of hepatitis C virus NS5B polymerase.

Randy W Jackson,Matthew G LaPorte,Torsten Herbertz,Tandy L Draper,Janet A Gaboury,Susan R Rippin,Ravi Patel,Srinivas K Chunduru,Christopher A Benetatos,Dorothy C Young,Christopher J Burns,Stephen M Condon

Bioorganic & Medicinal Chemistry Letters（2011）

引用 42|浏览13

暂无评分

摘要

We describe the structure–activity relationship of the C7-position of pyrano[3,4-b]indole-based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compounds 13 and 14.

查看译文

关键词

HCV NS5B polymerase,Pyranoindoles

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要