Novel chiral H3-receptor agonists.

R Lipp,J M Arrang, J Buschmann, M Garbarg,P Luger,W Schunack,J C Schwartz

Agents and actions. Supplements（1991）

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摘要

Several alkyl-substituted histamine derivatives have been synthesized and investigated for their agonistic potency on three classes of histamine receptors. While all investigated compounds are full agonists at H3-receptors their relative potency vs. histamine is strongly varying and culminates in alpha R, beta S-dimethylhistamine which is a highly potent and selective H3-receptor agonist.

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