Common variants at MS4A4/MS4A6E , CD2AP , CD33 and EPHA1 are associated with late-onset Alzheimer's disease

Adam C Naj,Gyungah Jun,Gary W Beecham,Li-San Wang,Badri Narayan Vardarajan,Jacqueline Buros,Paul J Gallins,Joseph D Buxbaum,Gail P Jarvik,Paul K Crane,Eric B Larson,Thomas D Bird,Bradley F Boeve,Neill R Graff-Radford,Philip L De Jager,Denis Evans,Julie A Schneider,Minerva M Carrasquillo,Nilufer Ertekin-Taner,Steven G Younkin,Carlos Cruchaga,John S K Kauwe,Petra Nowotny,Patricia Kramer,John Hardy,Matthew J Huentelman,Amanda J Myers,Michael M Barmada,F Yesim Demirci,Clinton T Baldwin,Robert C Green,Ekaterina Rogaeva,Peter St George-Hyslop,Steven E Arnold,Robert Barber,Thomas Beach,Eileen H Bigio,James D Bowen,Adam Boxer,James R Burke,Nigel J Cairns,Chris S Carlson,Regina M Carney,Steven L Carroll,Helena C Chui,David G Clark,Jason Corneveaux,Carl W Cotman,Jeffrey L Cummings,Charles DeCarli,Steven T DeKosky,Ramon Diaz-Arrastia,Malcolm Dick,Dennis W Dickson,William G Ellis,Kelley M Faber,Kenneth B Fallon,Martin R Farlow,Steven Ferris,Matthew P Frosch,Douglas R Galasko,Mary Ganguli,Marla Gearing,Daniel H Geschwind,Bernardino Ghetti,John R Gilbert,Sid Gilman,Bruno Giordani,Jonathan D Glass,John H Growdon,Ronald L Hamilton,Lindy E Harrell,Elizabeth Head,Lawrence S Honig,Christine M Hulette,Bradley T Hyman,Gregory A Jicha,Lee-Way Jin,Nancy Johnson,Jason Karlawish,Anna Karydas,Jeffrey A Kaye,Ronald Kim,Edward H Koo,Neil W Kowall,James J Lah,Allan I Levey,Andrew P Lieberman,Oscar L Lopez,Wendy J Mack,Daniel C Marson,Frank Martiniuk,Deborah C Mash,Eliezer Masliah,Wayne C McCormick,Susan M McCurry,Andrew N McDavid,Ann C McKee,Marsel Mesulam,Bruce L Miller,Carol A Miller,Joshua W Miller,Joseph E Parisi,Daniel P Perl,Elaine Peskind,Ronald C Petersen,Wayne W Poon,Joseph F Quinn,Ruchita A Rajbhandary,Murray Raskind,Barry Reisberg,John M Ringman,Erik D Roberson,Roger N Rosenberg,Mary Sano,Lon S Schneider,William Seeley,Michael L Shelanski,Michael A Slifer,Charles D Smith,Joshua A Sonnen,Salvatore Spina,Robert A Stern,Rudolph E Tanzi,John Q Trojanowski,Juan C Troncoso,Vivianna M Van Deerlin,Harry V Vinters,Jean Paul Vonsattel,Sandra Weintraub,Kathleen A Welsh-Bohmer,Jennifer Williamson,Randall L Woltjer,Laura B Cantwell,Beth A Dombroski,Duane Beekly,Kathryn L Lunetta,Eden R Martin,M Ilyas Kamboh,Andrew J Saykin,Eric M Reiman,David A Bennett,John C Morris,Thomas J Montine,Alison M Goate,Deborah Blacker,Debby W Tsuang,Hakon Hakonarson,Walter A Kukull,Tatiana M Foroud,Jonathan L Haines,Richard Mayeux,Margaret A Pericak-Vance,Lindsay A Farrer,Gerard D Schellenberg

NATURE GENETICS（2011）

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摘要

Gerard Schellenberg and colleagues report a genome-wide association study of late-onset Alzheimer's disease (LOAD), as part of the Alzheimer Disease Genetics Consortium. They identify common variants in MS4A4/MS4A6E , CD2AP , CD33 and EPHA1 associated with LOAD.

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关键词

epha1,alzheimer,ms4a4/ms4a6e,common variants,late-onset

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