Design and synthesis of a novel class of dual PPARgamma/delta agonists.

Isabel C Gonzalez, Jason Lamar,Fatima Iradier,Yanping Xu,Leonard L Winneroski, Jeremy York,Nathan Yumibe,Richard Zink,Chahrzad Montrose-Rafizadeh, Gary J Etgen, Carol L Broderick, Brian A Oldham,Nathan Mantlo

Bioorganic & medicinal chemistry letters（2007）

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摘要

The design and synthesis of dual PPAR gamma/delta agonist (R)-3-{2-ethyl-4-[3-(4-ethyl-2-pyridin-2-yl-phenoxy)-butoxy]-phenyl}propionic acid is described. This compound dose-dependently lowered plasma glucose in hyperglycemic male Zucker diabetic fatty (ZDF) rats and produced less weight gain relative to rosiglitazone at an equivalent level of glucose control.

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