SNP Variations in the 7q33 Region Containing DGKI are Associated with Dyslexia in the Finnish and German Populations

Four genes, DYX1C1 , ROBO1, DCDC2 and KIAA0319 have been studied both genetically and functionally as candidate genes for developmental dyslexia, a common learning disability in children. The identification of novel genes is crucial to better understand the molecular pathways affected in dyslectic individuals. Here, we report results from a fine-mapping approach involving linkage and association analysis in Finnish and German dyslexic cohorts. We restrict a candidate region to 0.3 Mb on chromosome 7q33. This region harbours the gene diacylglycerol kinase, iota ( DGKI ) which contains overlapping haplotypes associated with dyslexia in both Finnish and German sample sets.