FACTORS INFLUENCING MORBIDITY AND MORTALITY IN INFANTS WITH SEVERE RESPIRATORY-DISTRESS SYNDROME TREATED WITH SINGLE OR MULTIPLE DOSES OF A NATURAL PORCINE SURFACTANT
Biology of the neonate(1992)
摘要
In an international multicenter trial infants with clinical and radiological signs of severe RDS (age 2-15 h, birthweight 700-2,000 g, mechanical ventilation, FiO2 greater-than-or-equal-to 0.6, no complicating disease) were randomized to receive either a single dose (n = 176) or up to three subsequent doses (n = 167) of a natural porcine surfactant (Curosurf). Using a logistic regression model, the effects of therapy, birthweight, sex, hospital and other clinical factors on survival and various outcome parameters were evaluated. Mortality (13 vs. 21 %, p < 0.05) and the incidence of pneumothorax (9 vs. 18 %, p < 0.01) were significantly lower in the multiple-dose group. Low birthweight, hospital allocation, low Apgar score and initial disease severity were associated with an increased mortality. Low birthweight, hypothermia (admission temperature < 36-degrees-C) and acidosis (pH < 7.25) prior to surfactant treatment could be identified as risk factors for the development of intracranial hemorrhage.
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关键词
RESPIRATORY DISTRESS SYNDROME,PULMONARY SURFACTANTS,INFANT, NEWBORN
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