Comment on: Kim et al. (2010) Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight. Diabetes;59:2772-2780.

The article by Kim et al. (1) outlines a detailed series of experiments that purport to establish angiopoietin-like protein 4(Angptl4)/fasting- induced adipose factor (Fiaf) as a novel hypothalamic regulator of food intake and body weight in the mouse. Although the results of this study are impressive, we note that all previous publications on the regulation of fiaf in the murine brain were overlooked. For example, in our ongoing studies of adipokine gene expression in the nervous …