An enyne cycloisomerization approach to the triple reuptake inhibitor GSK1360707F.

Nicole M Deschamps,Vassil I Elitzin,Bing Liu,Mark B Mitchell,Matthew J Sharp,Elie A Tabet

JOURNAL OF ORGANIC CHEMISTRY（2011）

引用 51|浏览10

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摘要

The triple reuptake inhibitor GSK1360707F was synthesized via an efficient and scalable route that features an enyne cycloisomerization reaction catalyzed by either Pt(II) or Au(I). Key aspects of this work such as the choice of the nitrogen protecting group and initial en-antioselectivity studies are discussed.

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