Striking effect of hydroxamic acid substitution on the phosphodiesterase type 4 (PDE4) and TNF alpha inhibitory activity of two series of rolipram analogues: implications for a new active site model of PDE4.

E F Kleinman, E Campbell,L A Giordano,V L Cohan,T H Jenkinson,J B Cheng,J T Shirley, E R Pettipher, E D Salter,T A Hibbs,F M DiCapua, J Bordner

JOURNAL OF MEDICINAL CHEMISTRY(1998)

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