Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Cathy E Elks,John R B Perry,Patrick Sulem,Daniel I Chasman,Nora Franceschini,Chunyan He,Kathryn L Lunetta,Jenny A Visser,Enda M Byrne,Diana L Cousminer,Daniel F Gudbjartsson,Tõnu Esko,Bjarke Feenstra,Jouke-Jan Hottenga,Daniel L Koller,Zoltán Kutalik,Peng Lin,Massimo Mangino,Mara Marongiu,Patrick F McArdle,Albert V Smith,Lisette Stolk, Sophie H van Wingerden,Jing Hua Zhao,Eva Albrecht,Tanguy Corre,Erik Ingelsson,Caroline Hayward,Patrik K E Magnusson,Erin N Smith,Shelia Ulivi,Nicole M Warrington,Lina Zgaga,Helen Alavere,Najaf Amin,Thor Aspelund,Stefania Bandinelli,Inês Barroso,Gerald S Berenson,Sven Bergmann,Hannah Blackburn,Eric Boerwinkle,Julie E Buring,Fabio Busonero,Harry Campbell,Stephen J Chanock,Wei Chen,Marilyn C Cornelis,David Couper,Andrea D Coviello,Pio d'Adamo,Ulf de Faire,Eco J C de Geus,Panos Deloukas,Angela Döring,George Davey Smith,Douglas F Easton,Gudny Eiriksdottir,Valur Emilsson,Johan Eriksson,Luigi Ferrucci,Aaron R Folsom,Tatiana Foroud,Melissa Garcia,Paolo Gasparini,Frank Geller,Christian Gieger,Vilmundur Gudnason,Per Hall,Susan E Hankinson, Liana Ferreli,Andrew C Heath,Dena G Hernandez,Albert Hofman,Frank B Hu,Thomas Illig,Marjo-Riitta Järvelin,Andrew D Johnson,David Karasik, Kay-Tee Khaw,Douglas P Kiel,Tuomas O Kilpeläinen,Ivana Kolcic,Peter Kraft,Lenore J Launer,Joop S E Laven,Shengxu Li,Jianjun Liu,Daniel Levy,Nicholas G Martin,Wendy L McArdle,Mads Melbye,Vincent Mooser,Jeffrey C Murray,Sarah S Murray,Michael A Nalls,Pau Navarro,Mari Nelis,Andrew R Ness,Kate Northstone,Ben A Oostra,Munro Peacock,Lyle J Palmer,Aarno Palotie,Guillaume Paré,Alex N Parker,Nancy L Pedersen,Leena Peltonen,Craig E Pennell,Paul Pharoah,Ozren Polasek,Andrew S Plump,Anneli Pouta,Eleonora Porcu,Thorunn Rafnar,John P Rice,Susan M Ring,Fernando Rivadeneira,Igor Rudan,Cinzia Sala,Veikko Salomaa,Serena Sanna,David Schlessinger,Nicholas J Schork,Angelo Scuteri,Ayellet V Segrè,Alan R Shuldiner,Nicole Soranzo,Ulla Sovio,Sathanur R Srinivasan,David P Strachan,Mar-Liis Tammesoo,Emmi Tikkanen,Daniela Toniolo,Kim Tsui,Laufey Tryggvadottir,Jonathon Tyrer,Manuela Uda,Rob M van Dam,Joyce B J van Meurs,Peter Vollenweider,Gerard Waeber, Nicholas J Wareham,Dawn M Waterworth,Michael N Weedon,H Erich Wichmann,Gonneke Willemsen,James F Wilson,Alan F Wright,Lauren Young,Guangju Zhai,Wei Vivian Zhuang,Laura J Bierut, Dorret I Boomsma,Heather A Boyd,Laura Crisponi,Ellen W Demerath,Cornelia M van Duijn,Michael J Econs,Tamara B Harris,David J Hunter,Ruth J F Loos,Andres Metspalu,Grant W Montgomery,Paul M Ridker,Tim D Spector,Elizabeth A Streeten,Kari Stefansson,Unnur Thorsteinsdottir,André G Uitterlinden,Elisabeth Widen,Joanne M Murabito,Ken K Ong,Anna Murray

NATURE GENETICS（2010）

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摘要

Ken Ong and colleagues report meta-analysis of 32 genome-wide association studies for age at menarche. They identify 30 loci newly associated with age at menarche, including four that were previously associated with BMI.

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关键词

Epidemiology,Genetics,Genome-wide association studies,Reproductive biology,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics

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