Placental site trophoblastic tumor presenting as a friable cervical mass.

Purpose of investigotion Placental site trophoblastic tumor (PSTT) is a rare variant of gestational trophoblastic neoplasia (GTN) and primarily composed of intermediate trophoblasts In contrast to other forms of GTN. PSTT presents with only mildly elevated levels of beta-hCG and immunohistochemical staining of tissue samples is a helpful tool or diagnosis Case and Results A 38-year-old gravida 3, parity 3 female presented to the emergency department after three weeks of abnormal vaginal bleeding The uterus was mildly enlarged, midline, and mobile with minimal discomfort A necrotic, friable mass was protruding through the cervical os and biopsies were obtained. The scrum beta-hCG was 13 mlU/ml Computed tomography revealed a mass within the endometrial cavity and cervix but no significant lymphatic adenopathy or metastasis Immunohistochemical staining was positive for cytokeratin AE1/AE3, E-cadherin, human placental lactogen (hPL). and alpha inhibin Surgery was considered curative Conclusion PSTT presenting as a friable cervical mass is uncommon Biopsies of this mass lead to the correct diagnosis Several immunohistochemical stains are suggested in the literature to evaluate for PSTT Clinically. it is prudent for physicians to differentiate PSTT from other forms of GTN because of the poor response of PSTT to chemotherapy