Monobactam and aminoglycoside combination therapy against metallo-beta-lactamase-producing multidrug-resistant Pseudomonas aeruginosa screened using a 'break-point checkerboard plate'.

Hideki Araoka,Masaru Baba,Shinsuke Takagi,Naofumi Matsuno,Kazuya Ishiwata,Nobuaki Nakano,Masanori Tsuji,Hisashi Yamamoto,Sachiko Seo,Yuki Asano-Mori,Naoyuki Uchida,Kazuhiro Masuoka,Atsushi Wake,Shuichi Taniguchi,Akiko Yoneyama

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES（2010）

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摘要

Metallo-beta-lactamase-producing multidrug-resistant Pseudomonas aeruginosa (MDR P. aeruginosa) is a cause of life-threatening infections. With parenteral colistin not available in Japan, we treated MDR P. aeruginosa sepsis with monobactam and aminoglycoside combination therapy, with screening using a 'break-point checkerboard plate'.

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multidrug resistance

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