Passive-active immunization in infants of hepatitis Be antigen-positive mothers. Comparison of the efficacy of early and delayed active immunization.

P M Grosheide,Riwka Del Canho,R A Heijtink,Ad S M Nuijten,John Zwijnenberg,John R J Banffer,Yuriy W Wladimiroff,Meindert J Botman,J Adriaan Mazel, Gijsbert C De Gast,G C M L Christiaens,L J Gerards,W P F Fetter, Willem Baerts,Solko W Schalm

AMERICAN JOURNAL OF DISEASES OF CHILDREN（1993）

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摘要

Objective.-To assess the efficacy of late active immunization against hepatitis B concomitant with diphtheria, pertussis, tetanus, and polio vaccine in high-risk infants receiving hepatitis B immune globulin at birth. Design.-Randomized study of infants born to mothers positive for hepatitis B surface antigen (HBsAg) and hepatitis Be antigen (HBeAg).

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