MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR

    Proceedings of the National Academy of Sciences of the United States of America, Volume 108, Issue 12, 2011, Pages 4991-4996.

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    Keywords:
    micrornasmicrornacell linegenotypemutationMore(1+)

    Abstract:

    MicroRNA-122 (miR-122) is believed to stimulate hepatitis C virus (HCV) replication through interaction with two adjacent sites downstream of stem loop I (SLI) within the HCV 5' untranslated region (5' UTR). Recently, it was demonstrated that locked nucleic acid SPC3649-induced miR-122 antagonism suppressed HCV genotype 1a and 1b infectio...More

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