Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system

    Proceedings of the National Academy of Sciences of the United States of America, Volume 109, Issue 48, 2012, Pages 19757-19762.

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    Abstract:

    Chronic infection with hepatitis C virus (HCV) is an important cause of end stage liver disease worldwide. In the United States, most HCV-related disease is associated with genotype 1 infection, which remains difficult to treat. Drug and vaccine development was hampered by inability to culture patient isolates representing HCV genotypes 1...More

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