Conserved T cell receptor α-chain induces insulin autoantibodies

Proceedings of the National Academy of Sciences of the United States of America, Volume 105, Issue 29, 2008, Pages 10090-10094.

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Keywords:
t cell receptorconserved sequenceinsulinautoantibodiesdna primersMore(1+)

Abstract:

A fundamental question is what are the molecular determinants that lead to spontaneous preferential targeting of specific autoantigens in autoimmune diseases, such as the insulin B:9–23 peptide sequence in type 1 diabetes. Anti-insulin B:9–23 T cell clones isolated from prediabetic NOD islets have a conserved Vα-segment/Jα-segment, but no...More

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