A novel and high performance potentiometric arrayed flexible glucose biosensor based on microfluidic device

This study presents a novel process for fabricating microfluidic device by screen-printed technology to obtain the low cost and less time wasting. The poly-dimethylsiloxane (PDMS) was used as the upper cover of microfluidic device. Besides, the glucose sensing membrane was evaluated by the electrochemical impedance spectroscopy (EIS) to determine that the glucose sensing film had been modified successfully. In the concentration ranging from 100 mg/dL to 500 mg/dL of glucose solution, the sensitivity and linearity of ruthenium dioxide (RuO2) sensing membrane via microfluidic device were 0.256 mV(mg/dL)-1 and 0.998, respectively, which was better than at the static conditions. All experimental results demonstrated that the arrayed flexible glucose biosensor had good electrochemical characteristics including high sensitivity, good reproducibility and long-term stability.