Optical measurement on membrane roughness of neuroblastoma cells treated with amyloid-beta peptide and electric fields

Hueijyuan Pan,Rueilin Wang,Jianlong Xiao,Yujen Chang,Jiyen Cheng,Yunru Chen,Chauhwang Lee

Lasers and Electro-Optics Pacific Rim（2013）

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摘要

We measured the membrane roughness of neuroblastoma cells by non-interferometric wide-field optical profilometry. We found that the peptide related to Alzheimer's disease, Amyloid-beta 42, reduces membrane roughness, but direct-current electrical fields recover this effect.

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关键词

biomedical optical imaging,biomembranes,cellular biophysics,diseases,light interferometry,neurophysiology,alzheimer disease,amyloid-beta peptide,direct-current electrical fields,electric fields,membrane roughness,neuroblastoma cells,noninterferometric wide-field optical profilometry,optical measurement

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