Magnetically Actuated Soft Capsule With the Multimodal Drug Release Function.
IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division(2013)
摘要
In this paper, we present a magnetically actuated multimodal drug release mechanism using a tetherless soft capsule endoscope for the treatment of gastric disease. Because the designed capsule has a drug chamber between both magnetic heads, if it is compressed by the external magnetic field, the capsule could release a drug in a specific position locally. The capsule is designed to release a drug in two modes according to the situation. In the first mode, a small amount of drug is continuously released by a series of pulse type magnetic field (0.01-0.03 T). The experimental results show that the drug release can be controlled by the frequency of the external magnetic pulse. In the second mode, about 800 mm(3) of drug is released by the external magnetic field of 0.07 T, which induces a stronger magnetic attraction than the critical force for capsule's collapsing. As a result, a polymeric coating is formed around the capsule. The coated area is dependent on the drug viscosity. This paper presents simulations and various experiments to evaluate the magnetically actuated multimodal drug release capability. The proposed soft capsules could be used as minimally invasive tetherless medical devices with therapeutic capability for the next generation capsule endoscopy.
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关键词
medical robotics,drug delivery,endoscopes,diseases,tetherless soft capsule endoscope,magnetically actuated multimodal drug release capability evaluation,external magnetic field,magnetic micro-robot,magnetic flux density 0.07 t,next generation capsule endoscopy,capsule endoscope,magnetic attraction,polymer films,magnetic actuators,pulse type magnetic field series,magnetically actuated soft capsule,polymeric coating,magnetic flux density 0.01 t to 0.03 t,minimally invasive tetherless medical devices,drug chamber,drug delivery systems,drug viscosity,capsule collapsing critical force,magnetic fields,therapeutic capability,gastric disease treatment,external magnetic pulse frequency,viscosity,magnetic heads,drugs,bioinformatics,biomedical research
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