MicroRNA-1 promotes apoptosis of hepatocarcinoma cells by targeting apoptosis inhibitor-5 (API-5).

FEBS Letters（2015）

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摘要

•miR-1 suppresses the malignant properties of HCC in vitro and in vivo.•miR-1 and API-5 are inversely expressed in human primary HCC tissues.•miR-1 negatively regulates API-5 expression via binding to its 3′UTR.•miR-1 promotes apoptosis of hepatoma cells by directly targeting API-5.

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关键词

HCC,API-5,MET,HDAC4,FOXP1,CCND2,CXCR4,SDF-1

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