Efficacy Of Naftopidil For Nocturia In Male Patients With Lower Urinary Tract Symptoms: Comparison Of Morning And Evening Dosing

ObjectivesTo examine the difference in improvement of lower urinary tract symptoms between morning and evening dosing of (1)-blocker naftopidil.MethodsA total of 177 male patients with nocturia were included in the present study and randomized to morning or evening dosing of naftopidil. The International Prostate Symptom Score, quality of life index and nocturia quality of life index were compared between the two study groups at 12weeks.ResultsA total of 143 patients (morning group: n=70, evening group: n=73) were analyzed as a result of the dropout of 34 patients because of failure to give consent, adverse events and failure to attend. Nocturia, quality of life index and nocturia quality of life index at 12weeks were significantly better in the evening group compared with the morning group. In a multivariate model, both the dosing time of naftopidil and the initial nocturia quality of life index were significantly associated with change in nocturia quality of life index.ConclusionsEvening dosing of naftopidil seems to be more effective in treating nocturia in male patients with lower urinary tract symptoms.