Heterogeneity of PIK3CA mutational status at the single cell level in circulating tumor cells from metastatic breast cancer patients.

Marta Pestrin,Francesca Salvianti,Francesca Galardi,Francesca De Luca,Natalie Turner,Luca Malorni,Mario Pazzagli,Angelo Di Leo,Pamela Pinzani

Molecular Oncology（2015）

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摘要

Circulating Tumor Cells (CTCs) represent a “liquid biopsy of the tumor” which might allow real-time monitoring of cancer biology and therapies in individual patients. CTCs are extremely rare in the blood stream and their analysis is technically challenging.

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关键词

Liquid biopsy,Single-cell analysis,DEPArray™,CellSearch®,CTC heterogeneity

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