RNA over-editing of BLCAP contributes to hepatocarcinogenesis identified by whole-genome and transcriptome sequencing.

•There are widespread RNA editing events in the transcriptome of human liver tissue using NGS technology.•There is differential expression of RNA editing genes in HCC compared to non tumor liver.•BLCAP RNA over-editing contributes to hepatocarcinogenesis.•BLCAP RNA editing can activate the Akt/mTOR signaling pathway by affecting the phosphorylation levels.