AXIN1 and AXIN2 variants in gastrointestinal cancers.

•The AXIN1 and AXIN2 proteins are viewed as tumor suppressors in the Wnt pathway.•We assessed AXIN1/2 sequence variants in gastrointestinal cancers.•AXIN1 may be a tumor suppressor gene in hepatocellular carcinoma.•Germline AXIN2 mutations are linked to a colorectal cancer predisposition syndrome.•The role of AXIN1/2 mutations in other cancers remains to be established.